According to research conclusions*, a formulation combining alpha-glucosylrutin (also called AGR, ag-rutin, glucosylrutin) and Vitamin E use with a broad spectrum sunscreen is an effective preventive PMLE treatment. In clinical studies, 80% of people who have used this formulation have experienced a major improvement of their PMLE and most of them had no symptoms at all.
What clinical studies have found
I have to thank you sincerely for your wonderful antioxidant lotion!! For years I suffered with PLE and could not enjoy the outdoors, much less a vacation in a sunny destination. Because your product is so effective, I no longer have a problem! Thank you, Thank You! »
- Marie, Mont Sinai NY - USA
I began experiencing PMLE , or sun allergy, symptoms of varying degrees as a young teen. For years I've searched for products that could lessen or completely prevent the terrible itching and bumps that would appear every time I vacationed at the beach or spent a lot of time in the sun. I received this lotion in late July... just before leaving for a California beach vacation. I used the lotion as recommended: Before sun exposure and then reapplying every 2 hours while in the sun. I used SPF 4, 8, and 15 (so nothing above 15) while in the sun, over top of the Shirudo lotion. I did not develop ANY PMLE symptoms while on my vacation and came back with an amazing tan! »
- Lindsey, Kentucky
I used your agr+e lotion for the first time this year for my vacation in Aruba, I developed polymorphous about 5 years ago and we go to Aruba every year, I read a blog about it and so i bought a bottle....i was willing to try anything to prevent this horrible rash with i get on my chest and upper arms. Your lotion was magnicifient! It prevented it about 90% of what I usually get and with continued use it went away after 1 day..I couldnt believe it, so just wanted to say... thank you thank you thank you! I will always use it for this reason and I will certainly tell anyone I know with the same problem. »
- Luann , Clinton NY - USA
I just wanted to let you know how well your Antioxidant Moisturizing Body Lotion worked for me. I have been suffering from PMLE for years - the first time I had a reaction I was 17 and I have had a bad reaction to the sun every time I've gone south since. Before going on my vacation to Hawaii, I decided that enough was enough and I was going to do something about this so I could enjoy my time on the beach and outside when on vacation. I came across your product and saw the reviews it got so I decided to give it a try. I was in Hawaii for three and a half weeks and had no PMLE symptoms the entire time. It changed my vacation and will change the rest of my life as I know I can go to these places and enjoy myself without worrying about how much I've exposed my skin to the sun. Thank you so much, the product is incredible. »
- Kimberly, Ottawa - Canada
« Hi, my name is Eloise and I have PMLE for 25 years. I am the founder of Shirudo Cosmetics. At first I develop this lotion for myself but decided to make it available for everyone. From all the preventive PMLE treatments I’ve tried so far, it is the only solution that has reduced 90% of my symptoms and allowed me to fully enjoy a sun vacation for the first time since I was 12 years old. I use Shirudo AGR+E for 3 years now. I can enjoy beach vacations and outdoor activities all year long. I don't have to hide from the sun anymore.
Of course I keep using a good broad spectrum sunscreen, but not as strong as the one I have used before. An SPF 25 is now quite enough and I don't get any sunburn. One of the most surprising thing I realized while testing the lotion is that my skin is not as sensitive as I thought. Since I was a teen, I used a very high SPF (even going as high as SPF 100!) thinking that my skin was burning easily when actually it was my PMLE either causing this burning sensation, or making my skin more prone to sunburn. My PMLE is manageable now. My health is a priority and I developed this lotion with the best natural ingredients. No more corticosteroid, no more antihistaminic, and no more tanning sessions. »
- Eloise Camire,
founder of Shirudo Cosmetics & PMLE sufferer for 25 years.
The horrible truth about PMLE is the ‘polymorphous’ part, because everyone experiences it differently, no treatment is effective for all. Other polymorphous light eruption treatment exist (phototherapy, Beta-Carotene, nicotinamide, oral antihistaminic and anti-malaria tablet), all with more or less positive results. You have to try it for yourself and see if it's working or not. We strongly believe Alpha-glucosylrutin and Vitamin E use with a broad spectrum sunscreen is the most promising preventive treatment so far. It is simple, quick, and totally natural. Try it and send us your feedback. We want to improve the product and make it the best solution for all PMLE sufferers.
Important: Always consult a dermatologist to assure you are suffering from PMLE and no other type of sun related conditions (photoallergic contact dermatitis, solar urticaria, phototoxicity, eczema, etc). Our lotion cannot prevent other type of sun allergies. If you already have a PMLE rash at this moment, anti-itch preparation and cold compresses may produce some temporary relief. Some people experience improvement with oral antihistamine. Aloe Vera may also help reduce the burning sensation. Try AGR+E on your next vacation.
IN A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL STUDY BY HADSHIEW ET AL, THE EFFICACY OF A NEW TOPICAL FORMULATION WAS COMPARED WITH A BROAD-SPECTRUM SUNSCREEN. THE NEW PRODUCT CONTAINED 0.25% ALPHA-GLUCOSYLRUTIN (A NATURAL, MODIFIED FLAVONOID) AND 1% TOCOPHERYL ACETATE (VITAMIN E). THIRTY PATIENTS WITH A HISTORY OF PMLE WERE PRETREATED WITH THE FORMULATIONS 30 MINUTES PRIOR TO DAILY PHOTOPROVOCATION WITH UV-A IRRADIATION OF 60-100 J/CM2 TO THE UPPER ARMS.
THE AUTHORS FOUND A STATISTICALLY SIGNIFICANT DIFFERENCE (P <.001) BETWEEN THE ANTIOXIDANT-CONTAINING FORMULATIONS AND PLACEBO AND BETWEEN THE SUNSCREEN-ONLY FORMULATION. ONLY A SINGLE PATIENT TREATED WITH THE NEW ANTIOXIDANT UV-PROTECTIVE GEL FORMULATION DEVELOPED CLINICAL SIGNS OF PMLE IN THE AREA TREATED. IN COMPARISON, 62.1% OF THE PLACEBO-TREATED AREAS AND 41.3% OF THE SUNSCREEN-ONLY TREATED AREAS SHOWED MILD-TO-MODERATE SIGNS OF PMLE. THE AUTHORS SUGGESTED THAT COMBINING A POTENT ANTIOXIDANT WITH A BROAD-SPECTRUM SUNSCREEN IS FAR MORE EFFECTIVE IN PREVENTING PMLE THAN SUNSCREEN ALONE.
JEANMOUGIN ET AL STUDIED THE EFFECTIVENESS 0.25% ALPHA-GLUCOSYL-RUTIN, 1% VITAMIN E, AND A BROAD-SPECTRUM HIGHLY UVA–PROTECTIVE SUNSCREEN (SPF 15; PERSISTENT PIGMENTATION DARKENING 6) UNDER REAL SOLAR EXPOSURE CONDITIONS IN THE SPRING AND SUMMER. THE CREAM WAS APPLIED EVERY 2 HOURS AFTER THE FIRST SUMMER EXPOSURE. NO TOPICAL OR SYSTEMIC TREATMENTS TO PREVENT PMLE WERE USED; DERMATOLOGISTS CHECKED PATIENTS AFTER THE SUMMER WAS OVER AND INTERVIEWED THEM. IN THIS STUDY, 52 OF 54 PATIENTS FINISHED STUDY, AND 67% OF PATIENTS HAD NO ERUPTIONS, 19% HAD MINOR ERUPTIONS, AND 13% HAD SEVERE ERUPTIONS OF PMLE. PRURITUS, WHICH HAD BEEN PRESENT IN ALL PATIENTS THE YEAR PRECEDING THE STUDY, WAS NOT OBSERVED IN 69% OF PATIENTS AND WAS UNBEARABLE FOR ONLY 3 PATIENTS (COMPARED WITH 27 PATIENTS BEFORE THE STUDY PREPARATION WAS USED). THE DERMATOLOGIC ASSESSMENT WAS THAT GLOBAL EFFICACY WAS APPROXIMATELY 80%, WITH INADEQUATE RESULTS IN 10% OF CASES; SPECIFICALLY, IT WAS DEEMED EXCELLENT FOR 35 PATIENTS AND GOOD FOR 7 PATIENTS