Shirudo AGR+E and Sol+3

Shirudo's complete skincare system designed for people who experience polymorphous light eruption (PMLE) or sun-induced skin reactions. Formulated with alpha-glucosylrutin (glucosylrutin / AG-rutin) and powerful next-generation antioxidants, all our products help strengthen the skin’s natural defense against UV-triggered inflammation—without harsh ingredients or long pre-treatment protocols.

Which Shirudo Lotion is Right for You?

For the simplest routine, choose Sol+3— no separate sunscreen needed.
For full control or mineral-sunscreen users, choose AGR+E Daily Lotion with your preferred SPF. For the best results, combine either day lotion with AGR+E Night Lotion for 24-hour support. Use the chart below for more details.

PMLE Relief Product Comparison

AGR+E Daily Day Lotion Sol+3 Daily All-in-One AGR+E Night Overnight Lotion
When to Use DaytimeDuring sun exposure DaytimeDuring sun exposure NighttimeAfter sun, before bed
How Often to Apply Apply 15 min before sun exposure & at least every 2 hrs or after swimming, sweating or towel drying Apply 30 min before sun exposure & at least every 2 hrs or after swimming, sweating or towel drying Once per nightAfter cleansing
Where to Use Face & Body Body Face & Body
Sunscreen Required on Top Yes — alwaysNot a sunscreen; use SPF 30+ on top NoBuilt-in UVA + UVB filters included Not applicableNighttime use only
UV Filters Included None Yes4× fewer chemical filters than standard SPF 50 — high tolerance None
Key Active Ingredients Alpha-glucosylrutin (AGR) + Vitamin E Hydroxytyrosol, Resveratrol + Algae extract AGR (50% more than daily) + Vitamin E + Shea Butter
AGR Concentration High NoneDifferent antioxidant formula 50% more AGRHighest concentration available
Clinically Studied Yes80% efficacy in published studies YesAntioxidant-based; newer formulation YesSame studied AGR+E base
Skin Feel & Texture Lightweight, fast-absorbingLight enough to reapply every 2h Lightweight, no white castEasy one-step application every 2h Rich, nourishingMenthyl lactate + shea butter
Cooling / Soothing Effect Moderate Moderate IntensiveMenthyl lactate for post-sun relief
Fragrance-Free Yes Yes Yes
Natural Ingredients 99%+ HighContains some chemical UV filters 99%+
For Swimmers Best optionPair with waterproof sunscreen. Reapply both after swimming, sweating or towel drying Not idealNot waterproof; reapply after swimming, sweating or towel drying Not applicable
Ideal For Mineral sunscreen users, swimmers, those sensitive to chemical filters or having PMLE on the face Travel, beach, outdoor activities — simplest one-step routine Overnight repair & recovery after sun exposure

FAQs

Why are Shirudo AGR+E and Sol+3 the best options to prevent Polymorphous Light Eruption?

Shirudo AGR+E and Shirudo SOL+3 are among the most effective and practical PMLE solutions available, especially compared with strategies that require weeks of preparation or lifestyle changes that many people simply can’t maintain.

Why Shirudo stands out in real life:

  • Works without advance loading or preparation

  • Targets the oxidative trigger of PMLE directly

  • Topical = fast, localized, predictable

  • Easy to integrate under your favorite sunscreen

  • Useful for sudden sun exposure, travel, or unpredictable weather

  • Very high adherence compared to supplements, photo-therapy or “hardening”

For many PMLE sufferers, Shirudo is the difference between managing PMLE in theory vs actually living normally in the sun.
What is the difference between AGR+E and Sol+3?

Sol+3 is a newer formulation and can be used alone while sun exposed. It uses different and more powerful antioxidants than AGR+E and also combines UVA and UVB filters. It's a one-step process, you don't have to apply sunscreen after. We found that having only one product makes it easier to comply with frequent applications, a key factor for our products to be effective. It is also more off-white/pale yellow than pure yellow, as the original AGR+E lotion. Unless you swim all day, Sol+3 is a great option and easier to use. The downside is that is it not waterproof.

If you plan to spend a lot of time in the water, it's best to go with AGR+E lotion and a fully waterproof sunscreen on top. So far people who used our original AGR+E lotion had great success with the new Sol+3 formulation as well. A great solution is using Sol+3 in the daytime while sun-exposed and AGR+E Intensive Night Lotion at night. This way you are covered with 5 different types of antioxidants, including alpha-glucosylrutin that made the success of the original AGR+E formulation. 

AGR+E plus your favorite sunscreen and AGR+E Intensive Night Lotion at night is the option to go with if you plan to spend a lot of time in the water or if you have a specific sunscreen you prefer to use, like a mineral sunscreen with zinc for example, or a facial sunscreen using less comedogenic ingredients. With this option, you use AGR+E while sun-exposed, massage well, and then apply your sunscreen on top. It's a two steps process. Both options are equally good, it depends on your daily activities and sunscreen personal preferences. 
What products is best for me?

Both options are equally good, it depends on your daily activities and sunscreen personal preferences. We recommend using either Sol+3 and AGR+E Intensive Night Lotion or AGR+E body lotion and AGR+E Intensive Night Lotion.

Sol+3 is a one-step process, it does not require sunscreen on top. We found that having only one product makes it easier to comply with frequent applications, a key factor for our products to be effective. Sol+3 is easier to use. So far people who used our original AGR+E lotion had great success with the new Sol+3 formulation as well. A great solution is using Sol+3 in the daytime while sun-exposed and AGR+E Intensive Night Lotion at night. This way you are covered with 5 different types of antioxidants, including alpha-glucosylrutin that made the success of the original AGR+E formulation. The downside is that Sol+3 is it not waterproof.

AGR+E plus your favorite sunscreen and AGR+E Intensive Night Lotion at night is the option to go with if you plan to spend a lot of time in the water, have an intense physical activity with losts of sweat, or if you have a specific sunscreen you prefer to use, like a mineral sunscreen with zinc for example, or a facial sunscreen using less comedogenic ingredients. With this option, you use AGR+E while sun-exposed, massage well, and then apply your sunscreen on top. It's a two steps process you must repeat every 2 hours at least of after swimming/toweling.

Need More Help?

Please have a look at our complete FAQ page. If you don't find the answer you are looking for, please contact us, we quickly reply to all questions.