AGR+E Overnight PMLE Relief Lotion
Intensive Overnight Relief for Polymorphous Light Eruption (PMLE) - The Restorative Night Formula
If you've spent the day protecting your skin from PMLE triggers, give it the intensive overnight support it needs to recover and rebuild. Shirudo AGR+E Overnight PMLE Relief Lotion delivers 50% more alpha-glucosylrutin (AGR) than our daily formula, working while you sleep to help soothe sun-sensitive skin and support your skin's natural recovery process.
Apply once at night after cleansing. Works in combination with AGR+E Daily Lotion for complete day and night support.
What Makes Shirudo AGR+E Overnight Different?
While most PMLE solutions focus only on daytime protection, optimal skin support requires 24-hour care. Shirudo AGR+E Overnight Lotion provides intensive nighttime nourishment with a concentrated dose of alpha-glucosylrutin (AGR) combined with vitamin E, shea butter, and cooling menthyl lactate to help comfort skin after sun exposure and support overnight repair.
- Regular price
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$43.00 USD - Regular price
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$0.00 USD - Sale price
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$43.00 USD
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Who Is This For?
Shirudo AGR+E Night Lotion is designed for anyone who experiences:
✓ Polymorphous light eruption (PMLE) or polymorphic light eruption
✓ Sun allergy, sun poisoning, or sun rash symptoms
✓ Itchy red bumps, patches, or blisters after sun exposure
✓ Spring and early summer skin sensitivity to UV
✓ UV-triggered inflammation despite using sunscreen
✓ Sun-sensitive skin that needs daily support
Key Benefits
How to use
How Alpha-Glucosylrutin Works
PMLE is not caused by sunburn—it's a delayed immune reaction to UV exposure that continues even after you're out of the sun. UV light creates oxidative stress that can trigger inflammatory responses in PMLE-prone skin, often intensifying hours after exposure.
Alpha-glucosylrutin (AGR) is a stabilized form of rutin, a powerful flavonoid antioxidant derived from plants. Research shows that AGR helps reduce UV-induced oxidative stress and supports the skin's natural recovery processes. At night, when skin enters its natural repair cycle, concentrated AGR provides enhanced antioxidant support to help address daytime UV-triggered oxidative stress.
Vitamin E provides complementary antioxidant protection, while shea butter delivers deep moisturization to support skin barrier function. Menthyl lactate offers a cooling sensation to help comfort skin that may feel warm or reactive after sun exposure.
Unlike treatments that only address surface symptoms, this intensive overnight formula works with your skin's natural nighttime renewal process to support comprehensive recovery.
Ingredients
Product Details
- Size: 4oz / 118 ml tube
- Shelf life: 2 years unopened, 5 months after opening
- Storage: Cool, dark place away from direct sunlight
- pH: Skin-compatible (4.5-6.5)
- Texture: Rich lotion, absorbs within minutes
- Finish: Nourishing, non-greasy
- Color: Light yellow (natural color from AGR)
- Made in North America
- Testing: Not tested on animals (cruelty-free)
Shirudo AGR+E is among the most effective and practical PMLE solutions available
especially compared with strategies that require weeks of preparation or lifestyle changes that many people simply can’t maintain. For many PMLE sufferers, Shirudo AGR+E is the difference between managing PMLE in theory vs actually living normally in the sun.
Why Shirudo with alpha-glucosylrutin stands out in real life
Works without advance loading or preparation
Targets the oxidative trigger of PMLE directly
Topical = fast, localized, predictable
Useful for sudden sun exposure, travel, or unpredictable weather
Very high adherence compared to supplements or “hardening”
Very affordable compared to medical treatment and photo-therapy
FAQs
What is polymorphous light eruption (PMLE)?
Polymorphous light eruption (PMLE) is a delayed immune reaction of the skin to ultraviolet exposure, often appearing as an itchy rash after sun exposure.
How does alpha-glucosylrutin support sun-sensitive skin?
Alpha-glucosylrutin is an antioxidant flavonoid that helps reduce UV-induced oxidative stress and supports the skin’s response to sun exposure.
Do I need to start using this weeks before sun exposure?
No. This topical formula is designed for daily use and can be applied during periods of sun exposure without requiring long pre-treatment.
Is this set suitable for sensitive skin?
Yes. The AGR+E Day & Night Set is formulated for sensitive and reactive skin and is non-photosensitizing.
Is this product available in the USA and Canada?
Yes. The AGR+E Day & Night Set is available for purchase and shipping within the United States and Canada.
Clinical Evidence behind AGR+E
Why Alpha-Glucosylrutin & Vitamin E for PMLE?
Multiple peer-reviewed studies published in dermatology journals demonstrate that topical alpha-glucosylrutin combined with vitamin E significantly outperforms sunscreen alone in supporting PMLE-prone skin.
In randomized, double-blind, placebo-controlled studies:
- Only 1 patient out of 30 (3.3%) developed PMLE when using AGR + vitamin E formulation
- 62.1% developed PMLEwith placebo
- 41.3% developed PMLE with sunscreen alone
This research demonstrates that alpha-glucosylrutin provides benefits beyond standard sun protection by targeting the oxidative mechanisms that trigger PMLE reactions.
Clinical evidence under real solar exposure
Studies by Jeanmougin et Al on PMLE sufferers under real solar exposure condition (Spring and Summer) reveal global efficacy of 80%. PMLE sufferers applied this formulation every 2 hours of sun exposure.
Here is what the study revealed:
- 67.3% experienced no eruptions at all
- 19.2% had only minor eruptions
- 13.5% had severe eruptions
A combination of Alpha-glucosylrutin , Vitamin E and a broad-spectrum sunscreen is, by far, the best natural approach when dealing with Polymorphous Light Eruption or PMLE.